Yes. If you call the airline in advance, they can have someone available to assist you with everything.

I met a woman who has traveled to over twenty countries alone, so it can be done! She said she researched a lot beforehand and found out about accessibility and services in each city and country she visited. Being prepared was critical and she really enjoyed her experience.

Edit: word

A guy that I have known since Junior High wrote a book called "A Sense of the World: How a Blind Man Became History’s Greatest Traveler" about James Holman.

It's an excellent book and I highly recommend it. If James Holman could do that on his own in the early 1800s when there was nothing approaching the ADA laws, you can do it too.

Ryan Knighton does and writes about it. It's pretty funny stuff. His one in Egypt was great.