Probably. What software are you thinking about using? A blind friend of mine runs FreeNAS, and it works well for him. Personally, I just install Debian server and roll my own.

Sure, why not? Either use one of the downloadable solutions (freenas, etc.), or do your own (Ubuntu and ZFS is what I run). I end up just sshing from my main Windows 10 machine into the server, or you can work locally using something like speak-up.

It depends on your abilities. If you can read Braille, you could do tons of stuff on Linux/BSD including setting up a server for almost anything. The command line is particularly blind-friendly, and gives you very powerful access to the system.

If you don't read Braille then you'll need to find systems that can be web-administrated and be compatible with your screen reader software.

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Yes. My wife has had no trouble doing most admin on our ReadyNAS and I have recommended ReadyNAS to other blind people. So far no complaints. It is also a full linux computer so if you are more comfortable with command line you can SSH in and manage it from the shell.

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