New York, bar none. Best public transportation, despite its recent woes, and unparalleled opportunities for employment. Plus, good food.

Chicago and, to a lesser extent, Boston might also be acceptable. Basically nothing else.

I think it's more about where you live in the city, than which city you pick.

Downtown in any actual major city is going to be infinitely better than a suburb. Streets are aligned on a grid. Crosswalks chirp so you know when it's safe to cross. Buses run every 5 minutes on every street. Call an Uber or Lyft and it's there in 2 - 3 minutes, all day and all night. Grocery stores and restaurants deliver for a pretty small fee. There are always people around.

I know for sure that's true in New York and Chicago but also Seattle, San Francisco, San Diego, Denver, and many others.

Minneapolis is pretty decent. Excellent public transit, very walkable, a range of housing prices.

Calgary Alberta Canada is to avoid as much as possible:

I’ve lived there for 4, 5 years and I’m moving to Montreal for that main reason:

way better transit and better accessibility services for blind users.

Austin, TX

I’d pick something with weather and a vibe you like. As well as plants that won’t accidentally kill you or cliffs.