Sure! Why not?

There was a production company called The Penguin Project that put on plays where all the actors were people with disabilities. I saw two of their shows, Annie, and Beauty and the Beast. Each actor had a non-disabled partner who helped them with confidence, missed lines, and stage directions. There was a blind girl who played Belle one year and the orphanage director in Annie. With help of her partner, she did great!

This is an extreme case of how you could participate. However, with some O&M training geared to your specific stage movements, you could do just fine in many plays.

Yah though it will take some understanding from the hobby group so you may need to shop around for a group that meshes well with what the person needs.

You can get anything from just remembering the movements like a dance (which may involve more deliberate things like prop placements or counting steps that would need others on board) to the old style bloke in a black outfit holding the props and giving assistance. The accommodation needed would depend on the group and what they are going to be doing.