I have multiple monitors at home and at work, but I rarely use them. For my setups, I have my primary monitor on an arm that I can pull in really close (which makes a screen magnifier unnecessary for me). In both setups I have an L-shape configuration for my desk, so I have the second monitor on the other side (so it's off to my left). But because I need to be so close, I almost never use it (since I would need to lean over to it and strain my neck/back).

I've though of a couple ways to make the secondary monitor more useful, but haven't actually tried them. One would be to mount it on an arm as well, so that both monitors would be really close. I've also thought of somehow mounting it above the primary so that I could just look up at it, but that would need a really heavy-duty arm and honestly I'm not sure how practical it is.

Something else to consider is utilizing multiple desktops. Since I personally need to look over and totally shift focus from one screen to the other, having a second virtual desktop is essentially the same thing. On Windows 10, you can hit Ctrl+Win+Left/Right to switch between them and move windows between them with Win+Tab. Here's a video I found about it: https://youtu.be/7HJbPDxzDqU

Personally, I can't use two monitors. My field of vision is too narrow - it causes neck strain and I lose the cursor moving between the two, lots of head turning, etc. I have, however, switched to an ultrawide monitor for the extra screen real-estate (I'm a software developer) and have found it to be a good middle ground. I have it mounted on a monitor arm, so I can easily move it as-needed and free up more space on the desk.

Not sure if this could be helpful for you but my setup at work consists of two monitors where one of them has a docked Windows magnifier stretched to fill the whole screen. That way, if I need to show something to someone they can look at the normal monitor while I look at the magnified one.

If you already sit very close to the screen, I don't think it would be helpful to use two monitors to display multiple tabs at once since you're going to have to move around alot to make use of it. Better off just using one monitor efficiently.

I have been using a dual monitor setup for almost 10 years now. Switching to dual monitors was one of the best decisions I made. It improves productivity drastically. I use a 27 inch LED Asus and 25-inch LCD hp. I want to replace the 25 inch one with a 27 inch for consistency.

It does take some getting used to but not that long. Maybe a couple of weeks you'll get used to the new layout. While making that change you might want to invest in good wrist rest for your keyboard and mouse, especially the mouse.

Another thing to keep in mind would be the accessibility software you're using. Make sure it will work well in a dual monitor setup.

First off, a monitor arm will be your bestest friend for reducing neck strain.

Also, if you want a bigger monitor and think two might be too big, consider an ultrawide curved monitor. It's an expensive solution but probably the best to avoid having to crane your neck all the way over if you're super close to the screen.

Pretty sure You'll like the monitor arm at least though.

I use a 27 as my main and a 25 as a second. really the second is only useful for passive things like youtube. Its too far away to be really productive.

I have both my monitors on a homemade monitor stand, Wich allows me to rotate and move my monitors in almost every way

I used a 27inch monitor and got a monitor arm. It solved all my neck and back pain because I could just move it forward to suit my needs.

I would recommend a monitor arm that can support two monitors, and one that you can adjust freely.