No, it does not work well at all. My son is legally blind and I have helped him as he works his way through several Adobe classes - InDesign, Photoshop, Illustrator and Animate.

The icons for the tools can be only two sizes - normal and slightly larger. His biggest problem was that he couldn't really see the tools because of this.

What do they need to do with Photoshop? He was able to do assignments for things like cropping, adding text, adjusting white balance etc. but when it came to making repairs to an old photo, dust removal, etc. he simply couldn't see well enough to recognize where changes needed to be made.