So I would start with the accessibility setting upping the font and such adding shortcuts for the voice over aswell if needed. Then look into other home launchers, I use nova launcher with custom icons, so all my app icons are bright yellow on a black background, this helps me and may not be useful for others. And I use a clock widget called xperia clock and use the largest clock on my homescreen. The biggest issue I have found with accesabillity on android is non accessible apps where using the biggest font size makes apps break or cookies unable to accept. If your vision is past being able to read any of it then try a free trial of synapptic. It changes everything and comes with it's own voice over. Just it's not great with every app.