KDE is slowly becoming accessible, but it's really not there yet and you have to get sighted assistance to tweak the settings. I'd go with absolutely any distro that uses either Mate or Gnome. XFCE is another option but it's desktop icons and file manager (Thunar) aren't at all accessible, so you'll need to install pcmanfm or similar if you want a graphical file manager. LXDE also works pretty well, but I've only done limited testing on a Debian 10 system with it. Window managers like i3 are doable as well, but you need to do some fiddling with speech-dispatcher (if on arch at least), GTK_MODULES and tweak some gsettings and gtkrc values. I've done this before, so don't hesitate to reach out to me if you need to.
I've written **some** of this up in some articles on my website, namely
$1Sidenote: one hopes that he doesn't promote his website and social platforms too much in this sub. I almost always do it to help people, not to plug my own content, but I feel it comes across a little pushy sometimes.