I (41F) lost my right eye to a tumor as a child. People always comment that they would never know if I hadn't told them. My prosthesis is amazing and fits well. But I definitely notice that my lid droops a little more on that side (especially if I'm tired) and my eyebrows aren't level. It's extremely noticeable to me in every photo. I think the best thing that you can do is let her know that you're not pretending there isn't a difference but that she notices it more than others because it's HER face. You can't make her not notice it and she shouldn't have to act like it doesn't bother her. Give her time. And if that doesn't work, a therapist.

So I don't know your wife, or how she feels most loved, but if I were in your shoes here's a few things I would do:
I would constantly, continually reassure her with words of affirmation. In every greeting, in the beginning of every morning, I would make sure she knew that she was the most beautiful person in the whole world.
I would remind her that she's not in pain from her eye anymore, how much freedom that gives her to be more herself.
I would be honest about how others might view her, they might be freaked out a little, they might judge her. But fuck'em, the only opinion she should care about is her own. Who does SHE care about what she looks like?
Most likely, if people are being honest, they want their friends and family to care about what they look like, and not some random schmuck on the street.
Now, if your wife is anything like my fiancee that last part won't be helpful, but hey! You've gotta sprinkle in some cold hard logic every once in a while!

It's really great to be supportive of a blind spouse, but it's also good to give the person space to grieve and to have times of upset, if that is their personality. Personally, about once a month (though almost never during COVID so far) I have a small breakdown because of the mindfucks that do come with blindness, where I just need to curl up for about a half hour and cry out my frustration. My partner gives me the space for that and is there to hug it out afterwards. Sometimes I just need that to be normal/happy the rest of the time.

It's really hard to get someone to focus on the good stuff when the good stuff is just normal. It's pretty normal in most people's minds not to have pain and not to have a tumour. So that's not a plus. That's just normality, at least in her mind, and losing the eye is a problem.

So I wouldn't dive into trying to make it okay in that way.

I still have both my eyes and I look so damn normal people sometimes question whether there's anything wrong with me, so I don't have any direct experience of what your wife is going through. That said I remember having a very strong reaction to people telling me in a rather facile way that it was all okay, I was beautiful and desirable and everything was fine. I remember lying awake at night thinking about how no man would ever want to have anything to do with me. I was very very wrong, but your wife doesn't know that yet, so tread carefully.

My left eye was removed due to 24 hour a day glaucoma pain that could not be alleviated. (It was terrible!) While the procedure and recovery were pretty awful, I'm glad it finally got taken care of.

I felt really self conscious until I got my prosthetic eye. Once I got it, I was fine because nobody can tell my left eye isn't real from what I've been told. Hopefully she'll feel better once she has her prosthetic eye completed.

In the meantime, all you can do is be there for her. She'll be going through all sorts of things and that is perfectly normal.

It is proven that when something negative is said, it takes seven positive things to remove that effect initially, and seven more to feel positive about oneself. It is something that I have to remind my husband when he is feeling down because of his own sight loss. basically, don't just remind her that she is the most beautiful creature in the world but specific things that you love. encourage her to find things that she loves about herself. It is hard because we women put so much value on physical appearance. but if she can keep telling herself the ways that she loves herself rather then the negative she will pull herself out of it. IMPORTANT SIDENOTE: she will mourn the loss of her sight and how it is changing her, it is normal, perhaps when she is ready get into contact with people that are in like situations as more support for herself and for yourself as well.