As with the other comments I've struggled with getting to the right room in hospital appointments - I had a few annoyed nurses - and with shopping as I struggled to stay 2m away from people or follow the markers, my local supermarkets wouldn't allow me to bring a guide, and some refused to help me.
I also noticed that public transport was easier because it was quiet enough to hear the stop announcements and less busy, although social distances on buses is a nightmare

My lectures got moved over to zoom, which was surprisingly difficult! I think a lot of lecturers had so much else to do that describing images etc for me just slipped their minds
I also struggled with my guest lectures refusing to accommodate me both with online and face-to-face teaching, which wasn't a problem before

Social distancing, since social distancing markers aren’t tactile. I’ve heard some people struggle to get access to priority online shopping for groceries and such. Also you may be judged for touching stuff, but I don’t care about that. You may struggle to get assistance, support workers and sighted guides. Organisations possibly struggled to get services - I would recommend talking to them and asking about what they did and how their clients felt.
On the other hand, I’ve found everything going on Zoom amazing. Very accessible and decreased social isolation. This is all coming from an Australian perspective, and my state wasn’t hit particularly hard either so life’s been normal for the most part.

Similar things also shopping apps slots get taken up really quick. And really early so that’s another problem.

Many of my clients are older, and need to make hospital/medical care visits. However, many places don't allow other people to come in with them, which makes it difficult for the client to travel sometimes (or even for translation). Some places are more lenient than others and it isn't always consistent.