They have text to speech integration for GUI elements. Its been a while since I've looked into it but from what I saw Microsoft games have some of the best, at least in terms of mainstream games. Heres a video from illegally sighted reviewing Age of Empires.
$1The Last of US Part 2 has really good accessibility but you do have to have some sight to play. it has a color filter that you can toggle on and off that makes enemies appear red, it has a button which you can press to turn your character in the direction of the objective, auto-aim, and text to speech for text and user interface.
If you want multiplayer games I've heard good things from World of War craft, there are people that are totally blind who play it. Fighting games like Mortal Combat, skull girls, and tekkie are games blind people can play at high level since the opponent is always in front of you and moves have unique sounds.