I am VI and use Cakewalk (very nice and free). I also have a large 2nd monitor (22.5" x 12.5"). My screen resolution is 1920 x 1080 and scaling is set at 150%. I also recommend using Dark Mode whenever possible, since that makes the contrast better. Good luck!

Have you tried screen magnification? Good the Windows key and press plus. It'll zoom in your whole screen. Text won't be quite as crisp, but you don't have to rely on proper DPI scaling.

DAWs can be weird with UI scaling. I use Bitwig and the UI scales great but that does mean I have to scroll a lot for projects with many tracks and, naturally, none of the scaling carries over to 3rd party instruments. Because of that, I put it back in default scale and instead use a full-screen magnifier that follows my mouse like a camera. It's a little disorienting at first but I'm very used to it now, and it's LOADS better than scaling or leaning forward and squinting. I get to actually relax and have my back against the chair, that doesn't happen often. Good magnifiers will have options to turn on or off aliasing to make blurry zoomed-in things more crisp (or do the reverse, take away jaggy edges for a more natural look).

Most magnifier programs will come with high contrast settings as well and those can be great for text but will be hit-and-miss with a lot of DAW and plugin color schemes.

Considering that you'll be spending quite a bit of time in front of the computer, I'd suggest you learn how to use a screen reader.

Reaper is a very popular daw amongst VI musicians on windows. I have no experience with it myself but I believe there is a way to make it accessible with NVDA and the skins are highly customisable.

On the mac side of things Reaper, Protools and Logic Pro X can be used with voiceover.

Unfortunately daws in general are very information dense and can be very hard to use even if you have some usable sight. Maybe a control surface can help in this regard.

Hi OP. I'm a composer and editor and I use Reaper. I am not blind but I have poor vision and I have worn glasses since I was a kid.

One of my biggest pet peeves is how small everything is in a DAW where you basically need a magnifier to see anything.

Reaper is very customizable but also when you get down into the nuts and bolts it can be quite complex. However it does follow the standard DAW layout and is simple for the more basic production needs.

Check out this Reaper accessibility wiki and links. There is a DAW Accessibility Discord as well as Dropbox folder. $1

here are the instructions for joining the Discord

Open your browser of choice, go to its address bar and type https. Follow that up with a Colon, then two Forward Slashes.

Then type in tinyurl.com, and another Forward Slash.

Lastly, type in DAWDiscord, and hit Enter, click "Go" etc.

Remember, there shouldn't be any spaces anywhere in that link you've just assembled.

One other thing I wanted to add to the discussion is to recommend a few VSTs with large buttons and Scalable UI.

If you plan to use any Kontakt instruments or purchase Kontakt Retail most of the 8DIO libraries have really excellent large size UI that is easy to see, and easy to work in and very intuitive. 8DIO products require Kontakt Retail and do not work on the free Kontakt player by Native Instruments. However their upcoming Soundplaint products will work in their own native player.

Vital which is free is also a great Synth with a good layout and easy to see UI.

Here is the link for the Vital Synth $1

A DAW controller like a PreSonus FaderPort can enable you to adjust plugin parameters on a mixer instead of using your mouse and screen.

Or you can go the old school, prohibitively expensive analog gear route.

I use Pro Tools on a Mac with heavy use of screen magnification. Have always found the Mac screen magnifier vastly superior to the one Windows has