A good website is a good website.
I would rather have great content that's challenging to access rather than mediocre content that's easy to navigate. Of course it's best to have both, but if you're focusing on inclusion and ease of access instead of focusing on content you should reconsider your priorities. If a website is good enough I'll find a way to get to its contents.
For a good example of how to do it right please check out
$1. It's a nerdy online cartoon by Zach Weinersmith that's updated daily. The colors are soft and not garish, the dialog is large and easier to read than other online graphic novels or comics, the characters are drawn simply, with thick lines and not much detail. If you look at the archived comics it's easy to tell how much more accessible his modern stuff is than his early stuff.
If you want an example of how to do it wrong look at an online Batman comic. Dark colors, tiny printed dialog, characters in panels sometimes extend an arm or a leg into the next panel making the experience less linear, and the sound effects (POW! or BANG! or CRUNCH!) are impossible for a screen reader to decipher.