I can tell you some of what's possible but I can't tell you how to do it - my computer literacy skills are not too good.

* Your computer's resolution can be changed to make desktop icons bigger or smaller.
* Browsers can be zoomed in.
* The size and colors of your online text can be changed.
* If you prefer white text on a black background you can opt for dark mode.
* Screen reading software such as NVDA can read text aloud to you.

There is probably more you could do that I'm not aware of - hopefully someone with more experience than me will answer your question. How you go about making these changes probably depends on what operating system you have. If you have a specific configuration you want you can probably find step by step instructions on how to do it online with a Google search. If you can't figure something specific out just reply here with the details and I'll try to help.

Windows has a ton of accessibility features like increased font sizes, color inversion, text to speech. Click start and search for accessibility. If you're using Mac, search for accesdibility in the finder.

I use a screen inverter it helps a ton. I use a program called negative screen. It's free and way better than windows default color inverter.

What about zoomtext I notice no one brought that one up. What about something like that or fusion? Or even Jaws or nvda and learn to use a screen reader?

Also get other training because of vision loss like ILS and cane training.

Assuming you are using Windows, right click on your desktop. Select display settings, then scale and layout. Increase and see what point helps. Eventually it's kind of too much magnification percentage to work well. If that is the case, search "Windows Magnifier." Select full screen mode. You may want to figure out the hot keys for Windows Magnifier anyhow for when you need just occasional help. For me that is windows key plus the plus or minus key. I hope this helps you get more comfortable more quickly.

Consider getting a large 2nd monitor for your laptop. As long as you have an extra USB port to plug it in, it's easy to set up. That, plus all of the suggestions other people have made, should help quite a bit.

One little thing that helps me with mouse pointers is to enable the setting "show moose position when pressing control key".

I'll often lose track of where the pointer is. With that setting on, windows animates rings around the pointer location to make it easier to spot whenever you tap the control key.