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Blind and Visually Impaired Community

Full History - 2022 - 07 - 01 - ID#vp8mag
16
Interesting perspectives for those hoping for cures (self.Blind)
submitted by Amazing_Ad7386
As someone who's eternally curious and very fond of science and technology, I was perusing recent articles in the famous academic journal Nature and came across an interesting review article: $1. In sharp contrast to most aspects of society at the start of these roaring 20s, very positively exciting things appear to be happening in medicine.

The article basically looks back at the last decade of research in regrowing retinal cells (from the epithelium for our friends with RP to the ganglia for our friends with glaucoma) without the pressure in mainstream media for sensationalism. I know many people here have faced vision loss and are hurting a lot. For you, I would like to share the conclusion of this paper:


>As recently as a decade ago, restoration of visual function in degenerative retinal disease seemed an audacious and perhaps unattainable goal. Progress in regenerative medicine, gene therapy, and micro-electronic prosthetics have brought us closer to this achievement and inspire confidence that it can be attained. PSC-derived cellular transplantation is in advanced clinical trials for RPE replacement and is on the verge of human trials for photoreceptor replacement. While RGC transplants face greater hurdles, significant progress has been made in this domain as well. Prosthetic vision restoration through optoelectronic devices, optogenetic gene therapy, and small-molecule photoswitches are all in or nearing human clinical trial work, following successful animal model studies. **Progress in the first decade since identifying this audacious goal has been substantial, and it is likely that multiple vision restoration technologies will reach clinical use in the next decade.**

While I'd advice not to get your hopes up **too** much (there's always unknown unknown's research might get stuck at), it seems we have a very interesting and exciting decade ahead of us indeed. Cheers!
akrazyho 5 points 1y ago
That is where I’m at I’m just waiting for science to catch up. I just need some sort of artificial/and thetic retina or a retina transplant to be a thing. My ret and specialist did not wanna give me a timetable but ball parking he said in 12 to 15 years there’s gonna be some sort of solution obtainable by me.
Amazing_Ad7386 [OP] 2 points 1y ago
Especially if your RGCs are still fine that kinda looks more and more plausible.
Sewn27 4 points 1y ago
At 63, a lot of the science will be far beyond my years. However, if it gives hope to young people I am all for it. I am troubled that a lot of these therapies will be out of reach for too many people because of the cost. Insurance companies do not like to pay claims with new therapies.
Amazing_Ad7386 [OP] 2 points 1y ago
Yes, that would unfortunately constitute a major hurdle. But still, the cost of stem cell therapies isn't that bad, like 5 $ figures. That's a lot of money to me too but some chronic diseases cost that a year to control ... If it becomes more ubiquitous it also might become less expensive. I definitely hope you get to enjoy these advancements someday too!
Sewn27 2 points 1y ago
Who knows. With the expansion of science and knowledge growing in an exponential rate. I haven’t kick the bucket yet. Lol
Terry_Pie 2 points 1y ago
Thanks for sharing. I've been following development and research on treatments for the past couple of years and it's clear we've come a long way in the past decade. While I'm sure Hofstadter's Law will come into play, I think we will get there eventually.
Amazing_Ad7386 [OP] 1 points 1y ago
Wow, I didn't even know about this law (I never read Gödel, Escher, Bach while I'd really have to) but as a programmer I can totally relate. To be honest I don't expect anything this decade either (or at least not something affordable) but I'm really taken aback by the optimism in such a serious journal.
[deleted] 2 points 1y ago
[removed]
Amazing_Ad7386 [OP] 1 points 1y ago
For sure. You're right about how AI was used by Moderna to speed up vaccine development. $1 where they explain a lot of what they do with data science. Check it out!

I also know that drug discovery algorithms are already being used for ophthalmic medicine research. For example, there are $1 being tested in animals right now. Really curious to see how smart our computers turn out to be!
SiriuslyGranger 2 points 1y ago
Not always as great as it says and it doesn’t work for everyone. There’s no hope for mine for instance.
Amazing_Ad7386 [OP] 2 points 1y ago
Unfortunately certain forms of blindness are easier to treat than others, yes. It's kinda tragic. But I'm happy and excited for those who it will help nonetheless and I just hope they don't forget those still left "behind".
SiriuslyGranger 1 points 1y ago
True, I think sometimes it gives false hopes to some though it all depends.
Amazing_Ad7386 [OP] 4 points 1y ago
Yeah, definitely! There was this low vision ophthalmologist three decades ago at the hospital where they've been following me up for my entire life that used to hand wave parents' (including mine) concern and mourning away saying that in a couple of years they'd just use stem cells to fix everything. Obviously, our community is still here and in fact actually growing quickly. But I must say that if I follow the references I'm legitimately impressed with the concrete results achieved as a skeptically inclined person by that experience. We've gone from vague theories two decades ago that could be applicable to the visual system one day to small but significant concrete practical achievements in both the lab and the eye. Those don't yet add up to meaningful restoration of visual acuity **at all**, but some fundamental roadblocks have been cleared (such as identifying genes and proteins that are relevant).

I'm not really posting this to give people false hope because at best it's still going to take such a long time that you're just going to have to learn to deal with being blind and that you should learn to enjoy a blind life. (Maybe I'm speaking only for myself but sitting around waiting for even a decade isn't something I'd enjoy.) Rather I do feel excited that some people reading this have a rapidly increasing good chance of experiencing this miracle to some extent one day.
SiriuslyGranger -2 points 1y ago
You may want to make this clear. Though.
KillerLag 1 points 1y ago
A lot of unknowns ahead, but science continues forward. Since the start of my career 14 years ago, there have been advances I would not have expected.
Amazing_Ad7386 [OP] 1 points 1y ago
I have a similar experience. I have a rare eye disease called aniridia and although there is by no means a cure several (semi)condition specific managing treatments, implants and surgeries are in advanced stages of development. 10 years ago there was nothing, so I do intuitively agree with these researchers' assessment that ophthalmology has something going really well for it currently.
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