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The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity (elifesciences.org)
submitted 24d ago by OCTEL11
OCTEL11 [OP] 3 points 24d ago
What do you think about catecholamines being the drivers of cortical plasticity in learning? I think this paper is suggesting that the main/key function of norepinephrine is to shape/gate learning. I wonder what this means for norepinephrine and other catecholamines in the peripheral nervous system - perhaps they are involved in unconscious learning for example learned reflexes? What are your thoughts?
SelfAwareMachine 3 points 21d ago
Most brainstem structures drive downstream "plasticity", regardless of whatever convenient global transmitter is used.
The transmitters themselves have nothing directly to do with "learning" or "plasticity" at all.
The effect of dorsal column lesions in the primary somatosensory cortex and medulla of adult rats
The actual "learning" part only takes place at the local level, occurs independently of global signalling, and local changes probably drive the "global" signal pattern. Choline networks are an artifact of local processing, rather than driving local processing.
An independent regulator of global release pathways in astrocytes generates a subtype of extracellular vesicles required for postsynaptic function
The transmitters themselves have nothing directly to do with "learning" or "plasticity" at all.
The effect of dorsal column lesions in the primary somatosensory cortex and medulla of adult rats
The actual "learning" part only takes place at the local level, occurs independently of global signalling, and local changes probably drive the "global" signal pattern. Choline networks are an artifact of local processing, rather than driving local processing.
An independent regulator of global release pathways in astrocytes generates a subtype of extracellular vesicles required for postsynaptic function
HamiltonBrae 1 points 19d ago
rwell its not so hard to find papers about neurotransmitters modulating plasticity so a bit misleading i think
SelfAwareMachine 3 points 18d ago
Honestly the state of neuroscience research is so bad that there's very few hypothetical constructs that can't find support, regardless of whether they actually are able to make consistent predictions or not.
That being said, the number of papers asserting "neurotransmitters" directly modulate "plasticity" (whatever this actually means in context) has definitely peaked and is on the downslope.
Until we see a model with high predictive ability, replicability, and reproduceability, it's probably a good idea to be skeptical of any "general" neuroscience thought.
That being said, the number of papers asserting "neurotransmitters" directly modulate "plasticity" (whatever this actually means in context) has definitely peaked and is on the downslope.
Until we see a model with high predictive ability, replicability, and reproduceability, it's probably a good idea to be skeptical of any "general" neuroscience thought.
HamiltonBrae 1 points 18d ago
lol, the evidence is pretty overwhelming. i suggest you read more about it.
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